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Transient congenital hypothyroidism – too short to be transient
K Subramaniam
Department of Endocrinology, Silverline Hospital, Kochi, Kerala, India
Correspondence Address:
K Subramaniam
Department of Endocrinology, Silverline Hospital, Kochi, Kerala
India
Congenital hypothyroidism (CH) occurs due to thyroid dysgenesis, thyroid ectopy, and dyshormonogenesis. A proportion of CH is transient which might be due to iodine deficiency/excess or maternal antibody-mediated. Certain forms of dyshormonogenetic defects may cause transient hypothyroidism. Here is a report of a neonate with overt clinical and biochemical hypothyroidism, who on evaluation was found to have dyshormonogenesis with a homozygous mutation in dual oxidase 2 (DUOX2) gene. During infancy, she became euthyroid. Severe in utero deficiency of thyroid hormone, very short duration of hypothyroidism and first-reported mutation of the DUOX2 gene in the Indian subcontinent were interesting features in this infant.
How to cite this article:
Subramaniam K. Transient congenital hypothyroidism – too short to be transient.J Postgrad Med 2021;67:238-240
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How to cite this URL:
Subramaniam K. Transient congenital hypothyroidism – too short to be transient. J Postgrad Med [serial online] 2021 [cited 2023 Oct 1 ];67:238-240
Available from: https://www.jpgmonline.com/article.asp?issn=0022-3859;year=2021;volume=67;issue=4;spage=238;epage=240;aulast=Subramaniam;type=0 |
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