Journal of Postgraduate Medicine
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DRUG REVIEW
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Year : 2012  |  Volume : 58  |  Issue : 2  |  Page : 140-146  

Regadenoson

GM Bengalorkar, K Bhuvana, N Sarala, TN Kumar 
 Department of Pharmacology, Sri Devaraj Urs Medical College, Tamaka, Kolar, Karnataka, India

Correspondence Address:
G M Bengalorkar
Department of Pharmacology, Sri Devaraj Urs Medical College, Tamaka, Kolar, Karnataka
India

Single-photon emission computerized tomography for myocardial perfusion imaging (MPI) is a non-invasive technique. MPI is performed by subjecting the patient to exercise or by using a pharmacological stress agent. Regadenoson is a selective A 2A adenosine receptor agonist used when MPI with exercise is contraindicated. It binds to the A 2A receptor and stimulates adenylate cyclase, resulting in increased cAMP, which phosphorylates protein kinase A thereby opening the ATP-dependant potassium channels leading to hyperpolarization in the coronary vascular smooth muscle. After a single bolus dose of regadenoson 400 μg, a peak plasma concentration (C max ) of 13.6 ng/mL is attained in 1-4 min, with a terminal half-life of 2 h. It has a quick onset, short duration sufficient enough for hyperemic response, with comparable efficacy to adenosine, but with fewer side-effects. The adverse effects of this drug are dyspnea, headache, flushing, chest pain and atrioventricular block. Regadenoson is used for MPI in patients with co-morbid conditions like mild-to-moderate reactive airway disease, obstructive lung disease and renal impairment.


How to cite this article:
Bengalorkar G M, Bhuvana K, Sarala N, Kumar T N. Regadenoson.J Postgrad Med 2012;58:140-146


How to cite this URL:
Bengalorkar G M, Bhuvana K, Sarala N, Kumar T N. Regadenoson. J Postgrad Med [serial online] 2012 [cited 2023 Jan 28 ];58:140-146
Available from: https://www.jpgmonline.com/article.asp?issn=0022-3859;year=2012;volume=58;issue=2;spage=140;epage=146;aulast=Bengalorkar;type=0


 
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