Journal of Postgraduate Medicine
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Year : 2005  |  Volume : 51  |  Issue : 4  |  Page : 328-329  

Intramural pseudodiverticulosis of the esophagus

P Gregor1, G Nadir1, S Henning2, L Mathias1,  
1 Departments of Diagnostic Radiology, University Hospital Freiburg, Freiburg, Germany
2 Departments of Gastroenterology, University Hospital Freiburg, Freiburg, Germany

Correspondence Address:
P Gregor
Departments of Diagnostic Radiology, University Hospital Freiburg, Freiburg

How to cite this article:
Gregor P, Nadir G, Henning S, Mathias L. Intramural pseudodiverticulosis of the esophagus.J Postgrad Med 2005;51:328-329

How to cite this URL:
Gregor P, Nadir G, Henning S, Mathias L. Intramural pseudodiverticulosis of the esophagus. J Postgrad Med [serial online] 2005 [cited 2022 Aug 18 ];51:328-329
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A 57-year-old male with a history of chronic alcoholism consulted our university medical center because of intermittent dysphagia for two years. Endoscopy, performed in another hospital, had not revealed any diagnosis. The patient occasionally suffered from unintentional stool loss. Proctological examination had shown no pathological findings, however neurologic examination had revealed a sensory neuropathy.

Barium-contrast esophagogram (BariumŪ, Guerbet, Sulzbach, Germany) showed multiple flask-shaped outpouchings in the esophageal wall. On double contrast esophagogram, most of the outpouchings were still filled with barium [Figure 1]and [Figure 2]. A moderate stricture found in the upper esophagus [Figure 1] regressed slightly after the administration of butylscopolamin [Figure 2]. Esophagogram depicted small interconnecting intramural tracks [Figure 1].

Endoscopic examination revealed multiple small diverticula in the esophageal wall [Figure 3]. Histology revealed hyperplasia of the esophageal epithelia with signs of a moderate chronic esophagitis. Microbiological examination showed no pathological findings. Manometric examination revealed esophageal hypermotility. The patient received butylscopolamin for a symptomatic therapy.


Esophageal intramural pseudodiverticulosis (EIP) is a rare disorder that is characterized on esophagogram by multiple flask-shaped outpouchings in the esophageal wall.[1] The pseudodiverticula represent dilated excretory ducts of deep esophageal mucous glands.[2]

Levine et al . reported an incidence of 0.15% of EIP on 14350 studied barium esophagograms.[1] However, only about 200 cases of EIP have been published so far. Clinical presentation is in about 75% of the patients dysphagia.[3],[4] However, EIP can also be an incidental finding on esophagogram.[1],[3],[4]

The etiology of EIP remains unknown, however current data suggests that pseudodiverticulosis is not a primary disease of the esophagus, it is much more a consequence of chronic irritation by different causes like esophageal reflux, diabetes or chronic alcoholism.[3],[4] Esophageal inflammation has been reported in up to 90% of the patients with EIP.[3] Dilatation of the ducts might be caused by obstruction with inflammatory material or extrinsic compression due to periductal inflammation with fibrosis.[3] Disturbance of neurologic functions, e.g. diabetes mellitus can cause esophageal hypermotility, an entity that has only been reported in three cases of EIP.[3],[4] Additional chronic neural involvement, as in our patient, has not been described before. We consider the impaired neurologic function as causative factor, however, we do not have an evidence for a direct cause-effect relationship.

Patients often have associated strictures, mostly in the upper esophagus. Endoscopic bouginage of associated strictures is effective in treating dysphagia. Treatment of the underlying esophageal disease is mandatory, e.g., proton pump inhibitors in esophageal reflux disease, or (as in our case) butylscopolamin for motility disorders.[3],[4]

Intramural tracking is often seen in patients with EIP.[5] Although there is little known clinical significance of this finding, it is important in establishing differential diagnosis as intramural tracks should not be mistaken for ulceration or extramural barium collections associated with perforation.[5] The most important differential diagnosis is underlying esophageal carcinoma, which has to be excluded carefully.[1],[6] Plavsic et al . reported a much higher incidence of EIP in patients with esophageal carcinoma (4,5% of 245 patients) than in a control group (0.9% in a population of 6400).[6] This implies increased risk of esophageal carcinoma, although a causative relationship could not be established by the study.


1Levine MS, Moolten DN, Herlinger H, Laufer I. Esophageal intramural pseudodiverticulosis: a reevaluation. Am J Roentgenol 1986;147:1165-70.
2Luedtke P, Levine MS, Rubesin SE, Weinstein DS, Laufer I. Radiologic diagnosis of benign esophageal strictures: a pattern approach. Radiographics 2003;23:897-909.
3Hahne M, Schilling D, Arnold JC, Riemann JF. Esophageal intramural pseudodiverticulosis: review of symptoms including upper gastrointestinal bleeding. J Clin Gastroenterol 2001;33:378-82.
4Ritz JP, Germer CT, Zimmer T, Isbert C, Buhr HJ. Esophageal hypermotility associated with intramural pseudodiverticulosis. Primary esophageal disease or epiphenomena? Surg Endosc 2000;14:681.
5Canon CL, Levine MS, Cherukuri R, Johnson LF, Smith JK, Koehler RE. Intramural tracking: a feature of esophageal intramural pseudodiverticulosis. Am J Roentgenol 2000;175:371-4.
6Plavsic BM, Chen MY, Gelfand DW, Drnovsek VH, Williams JP 3rd, Kogutt MS, et al . Intramural pseudodiverticulosis of the esophagus detected on barium esophagograms: increased prevalence in patients with esophageal carcinoma. Am J Roentgenol 1995;165:1381-5.

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