Journal of Postgraduate Medicine
 Open access journal indexed with Index Medicus & EMBASE  
     Home | Subscribe | Feedback  

REVIEW ARTICLE
[View FULLTEXT] [Download PDF
 
Year : 2002  |  Volume : 48  |  Issue : 2  |  Page : 149-52  

Genetics of gallstone disease.

B Mittal, R Mittal 
 Department of Genetics, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow - 226014, India. , India

Correspondence Address:
B Mittal
Department of Genetics, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow - 226014, India.
India

Gallstone disease is a complex disorder where both environmental and genetic factors contribute towards susceptibility to the disease. Epidemiological and family studies suggest a strong genetic component in the causation of this disease. Several genetically derived phenotypes in the population are responsible for variations in lipoprotein types, which in turn affect the amount of cholesterol available in the gall bladder. The genetic polymorphisms in various genes for apo E, apo B, apo A1, LDL receptor, cholesteryl ester transfer and LDL receptor-associated protein have been implicated in gallstone formation. However, presently available information on genetic differences is not able to account for a large number of gallstone patients. The molecular studies in the animal models have not only confirmed the present paradigm of gallstone formation but also helped in identification of novel genes in humans, which might play an important role in pathogenesis of the disease. Precise understanding of such genes and their molecular mechanisms may provide the basis of new targets for rational drug designs and dietary interventions.


How to cite this article:
Mittal B, Mittal R. Genetics of gallstone disease. J Postgrad Med 2002;48:149-52


How to cite this URL:
Mittal B, Mittal R. Genetics of gallstone disease. J Postgrad Med [serial online] 2002 [cited 2022 May 25 ];48:149-52
Available from: https://www.jpgmonline.com/article.asp?issn=0022-3859;year=2002;volume=48;issue=2;spage=149;epage=52;aulast=Mittal;type=0


 
Wednesday, May 25, 2022
 Site Map | Home | Contact Us | Feedback | Copyright  and disclaimer