Journal of Postgraduate Medicine
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ORIGINAL ARTICLE
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Year : 1991  |  Volume : 37  |  Issue : 4  |  Page : 211-5  

Efficacy of 5-fluorouracil in combination with methoxyphenyl maleamic acid in murine tumors.

MA Indap, RY Ambaye 
 Bio-organic Unit, Tata Memorial Centre, Parel, Bombay.

Correspondence Address:
M A Indap
Bio-organic Unit, Tata Memorial Centre, Parel, Bombay.

Combination chemotherapy studies were carried out in vivo against sarcoma 180 (ascites)(S180) and Ehrlich (ascites) carcinoma (EAC) tumours using cytotoxic drugs and methoxyphenyl maleamic acid (MPMA), an intermediate in the synthesis of pyrrolidine-nitrogen-mustards. Preliminary data have suggested that the combination of 5-fluorouracil (5-FU) and methoxyphenyl maleamic acid (MPMA) was more active than 5-FU used singly against EAC tumour. The possible therapeutic potential of this combination was further investigated in EAC tumour.


How to cite this article:
Indap M A, Ambaye R Y. Efficacy of 5-fluorouracil in combination with methoxyphenyl maleamic acid in murine tumors. J Postgrad Med 1991;37:211-5


How to cite this URL:
Indap M A, Ambaye R Y. Efficacy of 5-fluorouracil in combination with methoxyphenyl maleamic acid in murine tumors. J Postgrad Med [serial online] 1991 [cited 2022 May 26 ];37:211-5
Available from: https://www.jpgmonline.com/article.asp?issn=0022-3859;year=1991;volume=37;issue=4;spage=211;epage=5;aulast=Indap;type=0


 
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