Journal of Postgraduate Medicine
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Year : 1976  |  Volume : 22  |  Issue : 4  |  Page : 161-170  

Studies on the mechanism of hypotensive action of a disubstituted piperazine derivative - (Part II)

NK Dadkar, Vaishali N Dadkar, UK Sheth 
 Department of Pharmacology, Seth G. S. Medical College, Parel, Bombay-400012, India

Correspondence Address:
N K Dadkar
Hoechst Research Centre, Mulund, Bombay-400080.
India

The mechanism of hypotensive action of R-1230, a new disub­stituted piperazine derivative was studied in anaesthetised normo­tensive cats. Rapid intravenous injection of R-1230 produced an immediate transient fall in blood pressure attributable to a direct peripheral vasodilator action as concluded from cat«SQ»s hindquarters«SQ» perfusion experiment. The prolonged secondary hypotensive re­sponse appeared to be of complex nature. Inhibition of centrally mediated pressor reflexes on intracerebroventricular administra­tion, accompanied by peripheral adrenergic blockade, points to the dual mechanism of drug induced hypotension. Results in decere­brate and spinal preparations indicated the lower brainstem region lo be the principal site of central hypotensive action.


How to cite this article:
Dadkar N K, Dadkar VN, Sheth U K. Studies on the mechanism of hypotensive action of a disubstituted piperazine derivative - (Part II).J Postgrad Med 1976;22:161-170


How to cite this URL:
Dadkar N K, Dadkar VN, Sheth U K. Studies on the mechanism of hypotensive action of a disubstituted piperazine derivative - (Part II). J Postgrad Med [serial online] 1976 [cited 2022 Sep 27 ];22:161-170
Available from: https://www.jpgmonline.com/article.asp?issn=0022-3859;year=1976;volume=22;issue=4;spage=161;epage=170;aulast=Dadkar;type=0


 
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