Studies on the mechanism of hypotensive action of a disubstituted piperazine derivative - (Part II)
NK Dadkar, Vaishali N Dadkar, UK Sheth
Department of Pharmacology, Seth G. S. Medical College, Parel, Bombay-400012, India
The mechanism of hypotensive action of R-1230, a new disubstituted piperazine derivative was studied in anaesthetised normotensive cats. Rapid intravenous injection of R-1230 produced an immediate transient fall in blood pressure attributable to a direct peripheral vasodilator action as concluded from cat«SQ»s hindquarters«SQ» perfusion experiment. The prolonged secondary hypotensive response appeared to be of complex nature. Inhibition of centrally mediated pressor reflexes on intracerebroventricular administration, accompanied by peripheral adrenergic blockade, points to the dual mechanism of drug induced hypotension. Results in decerebrate and spinal preparations indicated the lower brainstem region lo be the principal site of central hypotensive action.
N K Dadkar
Hoechst Research Centre, Mulund, Bombay-400080.
|How to cite this article:|
Dadkar N K, Dadkar VN, Sheth U K. Studies on the mechanism of hypotensive action of a disubstituted piperazine derivative - (Part II).J Postgrad Med 1976;22:161-170
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Dadkar N K, Dadkar VN, Sheth U K. Studies on the mechanism of hypotensive action of a disubstituted piperazine derivative - (Part II). J Postgrad Med [serial online] 1976 [cited 2022 May 18 ];22:161-170
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