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Ambulatory blood pressure monitoring in pheochromocytoma – paraganglioma: A single center experience
SS Memon1, P Srivastava1, M Karlekar1, H Thakkar2, T Bandgar1, KEM Pheochromocytoma Investigators*1
1 Department of Endocrinology, Seth GS Medical College and KEM Hospital, Mumbai, Maharashtra, India
2 Department of Radiology, Seth GS Medical College and KEM Hospital, Mumbai, Maharashtra, India
| Date of Submission | 21-Mar-2023 |
| Date of Decision | 15-Apr-2023 |
| Date of Acceptance | 02-May-2023 |
| Date of Web Publication | 04-Aug-2023 |
Correspondence Address:
T Bandgar,
Department of Endocrinology, Seth GS Medical College and KEM Hospital, Mumbai, Maharashtra
India
 Source of Support: None, Conflict of Interest: None DOI: 10.4103/jpgm.jpgm_208_23 PMID: 37555422
Context/Aims: Pheochromocytoma and paraganglioma (PPGL) are rare tumors, and data on ambulatory blood pressure monitoring (ABPM) in these patients and the effect of blocking on ABPM parameters is limited. We aimed to describe ABPM parameters in a cohort of PPGL at our center in western India.
Methods: Retrospective study of patients with PPGL whose ABPM data was available. Demographic details, secretory status, and ABPM data were retrieved. Coefficient of variability (CV) was calculated as standard deviation/mean in percentage.
Results: In the 39 included patients, mean age at presentation was 39.3 ± 14.2 yr; 20 (51.3%) were males, 25 (64.1%) hypertensive, and mean tumor diameter was 5.3 cm. In 18 patients whose baseline ABPM was done without medications, those with nocturnal blood pressure dipping (6/18, 33%) had higher serum metanephrines (median 313.2 vs. 34.7 pg/ml, P = 0.028). Despite normal office blood pressure (BP), 8.9% of systolic BP readings were >140 mmHg, and 1.2% were >160 mmHg. Among 29 patients with both pre and post-block ABPM, mean BP (systolic 121.6 vs. 132.5 mmHg, P = 0.014; diastolic 68.9 vs. 76.4 mmHg, P = 0.005) and percentage of BP readings above 140 mmHg (median 9.4% vs. 24.4%, P = 0.016) were significantly lowered after the preoperative blockade in hypertensive (n = 19) patients, whereas CV was similar. The post-blockade ABPM characteristics were similar in patients blocked with amlodipine or prazosin.
Conclusion: ABPM provides additional information about BP characteristics in PPGL. The preoperative blocking decreases the magnitude of BP excursions but does not affect BP variability.
Keywords: Ambulatory BP monitoring, blocking, paraganglioma, pheochromocytoma
How to cite this URL:
Memon S S, Srivastava P, Karlekar M, Thakkar H, Bandgar T, KEM Pheochromocytoma Investigators*. Ambulatory blood pressure monitoring in pheochromocytoma – paraganglioma: A single center experience. J Postgrad Med [Epub ahead of print] [cited 2023 Sep 26]. Available from: https://www.jpgmonline.com/preprintarticle.asp?id=382955 |
KEM Pheochromocytoma Investigators✭
✭KEM Pheochromocytoma
Investigators.
Jaiswal SK, Patil V,
Lila A,
Department of
Endocrinology, Seth GS
Medical College and KEM
Hospital, Mumbai
.
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