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    -  Koshy K G
    -  Kulkarni G B
    -  Nandeesh B N
    -  Taalapalli A V
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Primary diffuse leptomeningeal primitive neuroectodermal tumor presenting as chronic meningitis

1 Department of Neurology, NIMHANS, Bangalore, Karnataka, India
2 Department of Neuropathology, NIMHANS, Bangalore, Karnataka, India

Date of Submission16-Jun-2022
Date of Decision23-Jul-2022
Date of Acceptance08-Aug-2022
Date of Web Publication09-Mar-2023

Correspondence Address:
GB Kulkarni,
Department of Neurology, NIMHANS, Bangalore, Karnataka
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/jpgm.jpgm_495_22

PMID: 36891942

 :: Abstract 

Primary diffuse leptomeningeal primitive neuroectodermal tumor is a rare meningeal neoplasm which can masquerade as chronic meningitis. While the clinical presentation and radiological features may provide a clue to this condition, meningeal biopsy is essential to clinch the diagnosis. A high index of suspicion and a low threshold for re-evaluating cases of neuroinfection that do not respond to empirical therapy are essential in this scenario. We present the case of a nine year old boy who was initiated on antituberculous treatment for chronic meningitis with hydrocephalus. Meningeal biopsy revealed a primary diffuse leptomeningeal primitive neuroectodermal tumor.

Keywords: Cerebral primitive neuroectodermal tumor, chronic meningitis, malignant meningeal neoplasm, meningeal biopsy

How to cite this URL:
Koshy K G, Kulkarni G B, Nandeesh B N, Taalapalli A V. Primary diffuse leptomeningeal primitive neuroectodermal tumor presenting as chronic meningitis. J Postgrad Med [Epub ahead of print] [cited 2023 Apr 1]. Available from:



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Online since 12th February '04
2004 - Journal of Postgraduate Medicine
Official Publication of the Staff Society of the Seth GS Medical College and KEM Hospital, Mumbai, India
Published by Wolters Kluwer - Medknow