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| ADR REPORT |
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| Ahead of print
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Bullous hemorrhagic dermatosis: A rare cutaneous reaction of heparin
N Dhattarwal, R Gurjar
Department of Dermatology and STD, V.M.M.C. and Safdarjung Hospital, New Delhi, India
| Date of Submission | 23-Mar-2022 |
| Date of Decision | 15-Jul-2022 |
| Date of Acceptance | 18-Jul-2022 |
| Date of Web Publication | 23-Feb-2023 |
Correspondence Address:
N Dhattarwal,
Department of Dermatology and STD, V.M.M.C. and Safdarjung Hospital, New Delhi
India
 Source of Support: None, Conflict of Interest: None DOI: 10.4103/jpgm.jpgm_282_22 PMID: 36861545
Bullous hemorrhagic dermatosis is a rare cutaneous reaction of heparin, a commonly used anticoagulant. Exact etiopathogenesis remains elusive but immune related mechanisms as well as dose dependent relationship have been proposed. Clinically, it is characterized by asymptomatic, tense hemorrhagic bullae on extremities or abdomen occurring 5-21 days after initiation of therapy. We report bilateral symmetrically grouped lesions, in a previously unreported distribution of this entity in both the forearms in a 50-year-old male admitted with acute coronary syndrome on oral ecosprin, oral clopidogrel and subcutaneous enoxaparin. The condition is self-resolving and discontinuation of drug is not required.
Keywords: Bullous hemorrhagic dermatosis, heparin, adverse drug reaction
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