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Bullous hemorrhagic dermatosis: A rare cutaneous reaction of heparin

 Department of Dermatology and STD, V.M.M.C. and Safdarjung Hospital, New Delhi, India

Date of Submission23-Mar-2022
Date of Decision15-Jul-2022
Date of Acceptance18-Jul-2022
Date of Web Publication23-Feb-2023

Correspondence Address:
N Dhattarwal,
Department of Dermatology and STD, V.M.M.C. and Safdarjung Hospital, New Delhi
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/jpgm.jpgm_282_22

PMID: 36861545

 :: Abstract 

Bullous hemorrhagic dermatosis is a rare cutaneous reaction of heparin, a commonly used anticoagulant. Exact etiopathogenesis remains elusive but immune related mechanisms as well as dose dependent relationship have been proposed. Clinically, it is characterized by asymptomatic, tense hemorrhagic bullae on extremities or abdomen occurring 5-21 days after initiation of therapy. We report bilateral symmetrically grouped lesions, in a previously unreported distribution of this entity in both the forearms in a 50-year-old male admitted with acute coronary syndrome on oral ecosprin, oral clopidogrel and subcutaneous enoxaparin. The condition is self-resolving and discontinuation of drug is not required.

Keywords: Bullous hemorrhagic dermatosis, heparin, adverse drug reaction

How to cite this URL:
Dhattarwal N, Gurjar R. Bullous hemorrhagic dermatosis: A rare cutaneous reaction of heparin. J Postgrad Med [Epub ahead of print] [cited 2023 Apr 1]. Available from:



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Online since 12th February '04
2004 - Journal of Postgraduate Medicine
Official Publication of the Staff Society of the Seth GS Medical College and KEM Hospital, Mumbai, India
Published by Wolters Kluwer - Medknow