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Levetiracetam-induced gingival hyperplasia
J James, J Jose, VA Gafoor
Department of Neurology, Government Medical College, Kozhikode, Kerala, India
Correspondence Address:
J James,
Department of Neurology, Government Medical College, Kozhikode, Kerala
India
 Source of Support: None, Conflict of Interest: None DOI: 10.4103/jpgm.jpgm_1059_21 PMID: 35848684
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Levetiracetam is a new generation antiseizure medication which binds to synaptic vesicle protein SV2A and inhibits the release of neurotransmitters. Gingival hyperplasia is a common side effect of conventional antiseizure medications like phenytoin, but very rare with the newer ones. A 14-year-old boy was started on levetiracetam 250 mg twice daily after a generalized seizure. Five days later he presented with gingival swelling and painful oral aphthae, without lymphadenopathy or systemic symptoms. Blood investigations were normal. After one-month of stopping the drug, the lesions cleared. This case highlights the importance of maintaining good oral hygiene and periodic dental review in patients on antiseizure medications.
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