Journal of Postgraduate Medicine
 Open access journal indexed with Index Medicus & ISI's SCI  
Users online: 1908  
Home | Subscribe | Feedback | Login 
About Latest Articles Back-Issues Articlesmenu-bullet Search Instructions Online Submission Subscribe Etcetera Contact
 
Read this article

 


    Article Cited by others

TECHNOLOGY REVIEW

Drug repositioning: Re-investigating existing drugs for new therapeutic indications

Padhy B M, Gupta Y K

Year : 2011| Volume: 57| Issue : 2 | Page no: 153-160

   This article has been cited by
 
1 Drug Repurposing: An Effective Tool in Modern Drug Discovery
V. S. Kulkarni, V. Alagarsamy, V. R. Solomon, P. A. Jose, S. Murugesan
Russian Journal of Bioorganic Chemistry. 2023;
[Pubmed]  [Google Scholar] [DOI]
2 Access to medicines for rare diseases: A European regulatory roadmap for academia
Noa Rosenberg, Sibren van den Berg, Nina N. Stolwijk, Bart A. W. Jacobs, Hendrika C. Post, Anna M. G. Pasmooij, Saco J. de Visser, Carla E. M. Hollak
Frontiers in Pharmacology. 2023; 14
[Pubmed]  [Google Scholar] [DOI]
3 Prediction of Drug-Related Diseases Through Integrating Pairwise Attributes and Neighbor Topological Structures
Yingying Song, Hui Cui, Tiangang Zhang, Tingxiao Yang, Xiaokun Li, Ping Xuan
IEEE/ACM Transactions on Computational Biology and Bioinformatics. 2022; 19(5): 2963
[Pubmed]  [Google Scholar] [DOI]
4 The Neural Metric Factorization for Computational Drug Repositioning
Xinxing Yang, Genke Yang, Jian Chu
IEEE/ACM Transactions on Computational Biology and Bioinformatics. 2022; : 1
[Pubmed]  [Google Scholar] [DOI]
5 GCMM: graph convolution network based on multimodal attention mechanism for drug repurposing
Fan Zhang, Wei Hu, Yirong Liu
BMC Bioinformatics. 2022; 23(1)
[Pubmed]  [Google Scholar] [DOI]
6 Learning multi-scale heterogenous network topologies and various pairwise attributes for drug–disease association prediction
Hongda Zhang, Hui Cui, Tiangang Zhang, Yangkun Cao, Ping Xuan
Briefings in Bioinformatics. 2022;
[Pubmed]  [Google Scholar] [DOI]
7 Heterogeneous multi-scale neighbor topologies enhanced drug–disease association prediction
Ping Xuan, Xiangfeng Meng, Ling Gao, Tiangang Zhang, Toshiya Nakaguchi
Briefings in Bioinformatics. 2022;
[Pubmed]  [Google Scholar] [DOI]
8 Drug repositioning based on heterogeneous networks and variational graph autoencoders
Song Lei, Xiujuan Lei, Lian Liu
Frontiers in Pharmacology. 2022; 13
[Pubmed]  [Google Scholar] [DOI]
9 Integration of Neighbor Topologies Based on Meta-Paths and Node Attributes for Predicting Drug-Related Diseases
Ping Xuan, Zixuan Lu, Tiangang Zhang, Yong Liu, Toshiya Nakaguchi
International Journal of Molecular Sciences. 2022; 23(7): 3870
[Pubmed]  [Google Scholar] [DOI]
10 Pretreatment with Zonisamide Mitigates Oxaliplatin-Induced Toxicity in Rat DRG Neurons and DRG Neuron–Schwann Cell Co-Cultures
Shizuka Takaku, Kazunori Sango
International Journal of Molecular Sciences. 2022; 23(17): 9983
[Pubmed]  [Google Scholar] [DOI]
11 Locally Applied Repositioned Hormones for Oral Bone and Periodontal Tissue Engineering: A Narrative Review
Gamal Abdel Nasser Atia, Hany K. Shalaby, Mehrukh Zehravi, Mohamed Mohamady Ghobashy, Zubair Ahmad, Farhat S. Khan, Abhijit Dey, Md. Habibur Rahman, Sang Woo Joo, Hasi Rani Barai, Simona Cavalu
Polymers. 2022; 14(14): 2964
[Pubmed]  [Google Scholar] [DOI]
12 Review of bioinformatics in Azheimer's Disease Research
Shida He, Lijun Dou, Xuehong Li, Ying Zhang
Computers in Biology and Medicine. 2022; : 105269
[Pubmed]  [Google Scholar] [DOI]
13 RP-HPLC method development, validation, and drug repurposing of sofosbuvir pharmaceutical dosage form: A multidimensional study
Ghulam Rasool Mangrio, Apichit Maneengam, Zunera Khalid, Tassadaq Hussain Jafar, Ghulam Qadir Chanihoon, Rayan Nassani, Ahsanullah Unar
Environmental Research. 2022; : 113282
[Pubmed]  [Google Scholar] [DOI]
14 Probenecid induces the recovery of renal ischemia/reperfusion injury via the blockade of Pannexin 1/P2X7 receptor axis
Walaa H. El-Maadawy, Marwa Hassan, Mohamed H. Badawy, AbdulRahman AbuSeada, Ehab Hafiz
Life Sciences. 2022; 308: 120933
[Pubmed]  [Google Scholar] [DOI]
15 A systematic review on data mining application in Parkinson's disease
Adesh Kumar Srivastava, Klinsega Jeberson, Wilson Jeberson
Neuroscience Informatics. 2022; : 100064
[Pubmed]  [Google Scholar] [DOI]
16 Simultaneous Delivery of Doxorubicin and Protease Inhibitor Derivative to Solid Tumors via Star-Shaped Polymer Nanomedicines Overcomes P-gp- and STAT3-Mediated Chemoresistance
Libor Kostka, Ladislav Sivák, Vladimír Šubr, Jirina Kovárová, Milada Šírová, Blanka Ríhová, Radislav Sedlacek, Tomáš Etrych, Marek Kovár
Biomacromolecules. 2022;
[Pubmed]  [Google Scholar] [DOI]
17 Daptomycin suppresses tumor migration and angiogenesis via binding to ribosomal protein S19 in humans
Sung Min Cho, Hwa Jung Lee, Peter Karuso, Ho Jeong Kwon
The Journal of Antibiotics. 2021; 74(10): 726
[Pubmed]  [Google Scholar] [DOI]
18 Rational drug repurposing for cancer by inclusion of the unbiased molecular dynamics simulation in the structure-based virtual screening approach: Challenges and breakthroughs
Farzin Sohraby, Hassan Aryapour
Seminars in Cancer Biology. 2021; 68: 249
[Pubmed]  [Google Scholar] [DOI]
19 Repurposing old molecules for new indications: Defining pillars of success from lessons in the past
Niti Mittal, Rakesh Mittal
European Journal of Pharmacology. 2021; 912: 174569
[Pubmed]  [Google Scholar] [DOI]
20 The Contribution of Clinical Pharmacologists in Precision Medicine: An Opportunity for Health Care Improvement
Davide Grisafi, Alessandro Ceschi, Veronica Avalos Clerici, Francesco Scaglione
Current Therapeutic Research. 2021; 94: 100628
[Pubmed]  [Google Scholar] [DOI]
21 Drug repurposing of dextromethorphan as a cellular target for the management of influenza
Tammy H. Cummings, Joseph Magagnoli, James W. Hardin, S. Scott Sutton
Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy. 2021; 41(10): 796
[Pubmed]  [Google Scholar] [DOI]
22 Repurposing Small Molecules to Target PPAR-? as New Therapies for Peripheral Nerve Injuries
Melissa L. D. Rayner, Jess Healy, James B. Phillips
Biomolecules. 2021; 11(9): 1301
[Pubmed]  [Google Scholar] [DOI]
23 Natural Products Are a Promising Source for Anthelmintic Drug Discovery
K. L. T. Dilrukshi Jayawardene, Enzo A. Palombo, Peter R. Boag
Biomolecules. 2021; 11(10): 1457
[Pubmed]  [Google Scholar] [DOI]
24 Graph Convolutional Autoencoder and Fully-Connected Autoencoder with Attention Mechanism Based Method for Predicting Drug-Disease Associations
Ping Xuan, Ling Gao, Nan Sheng, Tiangang Zhang, Toshiya Nakaguchi
IEEE Journal of Biomedical and Health Informatics. 2021; 25(5): 1793
[Pubmed]  [Google Scholar] [DOI]
25 Brief Overview of Approaches and Challenges in New Antibiotic Development: A Focus On Drug Repurposing
Natalie K. Boyd, Chengwen Teng, Christopher R. Frei
Frontiers in Cellular and Infection Microbiology. 2021; 11
[Pubmed]  [Google Scholar] [DOI]
26 Antidepressants and Antipsychotic Agents as Repurposable Oncological Drug Candidates
Michal Antoszczak, Anna Markowska, Janina Markowska, Adam Huczynski
Current Medicinal Chemistry. 2021; 28(11): 2137
[Pubmed]  [Google Scholar] [DOI]
27 Developing Novel Anticancer Drugs for Targeted Populations: An Update
Tadesse B. Tafesse, Mohammed H. Bule, Fazlullah Khan, Mohammad Abdollahi, Mohsen Amini
Current Pharmaceutical Design. 2021; 27(2): 250
[Pubmed]  [Google Scholar] [DOI]
28 Prediction of drug–disease associations by integrating common topologies of heterogeneous networks and specific topologies of subnets
Ling Gao, Hui Cui, Tiangang Zhang, Nan Sheng, Ping Xuan
Briefings in Bioinformatics. 2021;
[Pubmed]  [Google Scholar] [DOI]
29 Will the COVID-19 Pandemic Finally Fuel Drug Repurposing Efforts?
Anna Chen, Shivangi Patel, Matthew Alcusky, Vittorio Maio
American Journal of Medical Quality. 2021; 36(2): 122
[Pubmed]  [Google Scholar] [DOI]
30 The Current Challenges for Drug Discovery in CNS Remyelination
Sonia Balestri, Alice Del Giovane, Carola Sposato, Marta Ferrarelli, Antonella Ragnini-Wilson
International Journal of Molecular Sciences. 2021; 22(6): 2891
[Pubmed]  [Google Scholar] [DOI]
31 Current and Novel Therapies Against Helminthic Infections: The Potential of Antioxidants Combined with Drugs
Nuno Vale, Maria João Gouveia, Fátima Gärtner
Biomolecules. 2020; 10(3): 350
[Pubmed]  [Google Scholar] [DOI]
32 Drug repurposing against Parkinson's disease by text mining the scientific literature
Yongjun Zhu, Woojin Jung, Fei Wang, Chao Che
Library Hi Tech. 2020; 38(4): 741
[Pubmed]  [Google Scholar] [DOI]
33 NF-?B Inhibitors Attenuate MCAO Induced Neurodegeneration and Oxidative Stress—A Reprofiling Approach
Awais Ali, Fawad Ali Shah, Alam Zeb, Imran Malik, Arooj Mohsin Alvi, Lina Tariq Alkury, Sajid Rashid, Ishtiaq Hussain, Najeeb Ullah, Arif Ullah Khan, Phil Ok Koh, Shupeng Li
Frontiers in Molecular Neuroscience. 2020; 13
[Pubmed]  [Google Scholar] [DOI]
34 Biapenem as a Novel Insight into Drug Repositioning against Particulate Matter-Induced Lung Injury
Wonhwa Lee, Moon-Chang Baek, Kyung-Min Kim, Jong-Sup Bae
International Journal of Molecular Sciences. 2020; 21(4): 1462
[Pubmed]  [Google Scholar] [DOI]
35 Recycling the Purpose of Old Drugs to Treat Ovarian Cancer
Mariana Nunes, Miguel Henriques Abreu, Carla Bartosch, Sara Ricardo
International Journal of Molecular Sciences. 2020; 21(20): 7768
[Pubmed]  [Google Scholar] [DOI]
36 The potential of drug repositioning as a short-term strategy for the control and treatment of COVID-19 (SARS-CoV-2): a systematic review
William Gustavo Lima, Júlio César Moreira Brito, Joerg Overhage, Waleska Stephanie da Cruz Nizer
Archives of Virology. 2020; 165(8): 1729
[Pubmed]  [Google Scholar] [DOI]
37 Physicochemical characterization and in vitro biological evaluation of solid compounds from furazolidone-based cyclodextrins for use as leishmanicidal agents
Suzana Gonçalves Carvalho, Daniel Fernandes Cipriano, Jair Carlos Checon de Freitas, Miguel Ângelo Schettino Junior, Enrique Ronald Yapuchura Ocaris, Carolina Bioni Garcia Teles, Aurileya de Jesus Gouveia, Ricardo Pereira Rodrigues, Marcos Santos Zanini, Janaína Cecília Oliveira Villanova
Drug Delivery and Translational Research. 2020; 10(6): 1788
[Pubmed]  [Google Scholar] [DOI]
38 Identification of novel analgesics through a drug repurposing strategy
Parisa Gazerani
Pain Management. 2019; 9(4): 399
[Pubmed]  [Google Scholar] [DOI]
39 Drug repositioning through integration of prior knowledge and projections of drugs and diseases
Ping Xuan, Yangkun Cao, Tiangang Zhang, Xiao Wang, Shuxiang Pan, Tonghui Shen, Jonathan Wren
Bioinformatics. 2019; 35(20): 4108
[Pubmed]  [Google Scholar] [DOI]
40 Identification of Novel Cdc7 Kinase Inhibitors as Anti-Cancer Agents that Target the Interaction with Dbf4 by the Fragment Complementation and Drug Repositioning Approach
An Ning Cheng, Yu-Kang Lo, Yi-Sheng Lin, Tswen-Kei Tang, Chun-Hua Hsu, John T.-A. Hsu, Alan Yueh-Luen Lee
EBioMedicine. 2018; 36: 241
[Pubmed]  [Google Scholar] [DOI]
41 Clotrimazole inhibits the Wnt/ß-catenin pathway by activating two eIF2a kinases: The heme-regulated translational inhibitor and the double-stranded RNA-induced protein kinase
Honami Yonezawa, Mami Ogawa, Sota Katayama, Yui Shimizu, Norikazu Omori, Yusuke Oku, Tomoko Sakyo, Yoshimasa Uehara, Naoyuki Nishiya
Biochemical and Biophysical Research Communications. 2018; 506(1): 183
[Pubmed]  [Google Scholar] [DOI]
42 Repositioning of Omarigliptin as a once-weekly intranasal Anti-parkinsonian Agent
Bassam M. Ayoub, Shereen Mowaka, Marwa M. Safar, Nermeen Ashoush, Mona G. Arafa, Haidy E. Michel, Mariam M. Tadros, Mohamed M. Elmazar, Shaker A. Mousa
Scientific Reports. 2018; 8(1)
[Pubmed]  [Google Scholar] [DOI]
43 Common Dysregulation of Ribosomal Genes Present in Infants with Acute Respiratory Infection of Respiratory Syncytial Virus, Rhinovirus, and Influenza A
Huilan Zhu,Xinxin Xin
Pediatric Allergy, Immunology, and Pulmonology. 2015; 28(1): 32
[Pubmed]  [Google Scholar] [DOI]
44 Anti-inflammatory effects of methylthiouracil in vitro and in vivo
Sae-Kwang Ku,Moon-Chang Baek,Jong-Sup Bae
Toxicology and Applied Pharmacology. 2015; 288(3): 374
[Pubmed]  [Google Scholar] [DOI]
45 Novel insight into drug repositioning: Methylthiouracil as a case in point
Moon-Chang Baek,Byeongjin Jung,Hyejin Kang,Hyun-Shik Lee,Jong-Sup Bae
Pharmacological Research. 2015; 99: 185
[Pubmed]  [Google Scholar] [DOI]
46 In vitro anti-osteoclastogenic activity of p38 inhibitor doramapimod via inhibiting migration of pre-osteoclasts and NFATc1 activity
Seong-Hee Moon,Sik-Won Choi,Seong Hwan Kim
Journal of Pharmacological Sciences. 2015; 129(3): 135
[Pubmed]  [Google Scholar] [DOI]
47 Design, synthesis and anticancer properties of novel oxa/azaspiro[4,5]trienones as potent apoptosis inducers through mitochondrial disruption
D. Yugandhar,V. Lakshma Nayak,Sivakumar Archana,Kunta Chandra Shekar,Ajay Kumar Srivastava
European Journal of Medicinal Chemistry. 2015; 101: 348
[Pubmed]  [Google Scholar] [DOI]
48 Ameliorative effect of methylthiouracil on TGFBIp-induced septic responses
Byeongjin Jung,Sae-Kwang Ku,Jong-Sup Bae
Biochemical and Biophysical Research Communications. 2015; 463(4): 661
[Pubmed]  [Google Scholar] [DOI]
49 Integrating sampling techniques and inverse virtual screening: toward the discovery of artificial peptide-based receptors for ligands
Germán M. Pérez,Luis A. Salomón,Luis A. Montero-Cabrera,José M. García de la Vega,Marcello Mascini
Molecular Diversity. 2015;
[Pubmed]  [Google Scholar] [DOI]
50 Auranofin efficacy against MDRStreptococcus pneumoniaeandStaphylococcus aureusinfections
Leire Aguinagalde,Roberto Díez-Martínez,Jose Yuste,Inmaculada Royo,Carmen Gil,Íñigo Lasa,Mar Martín-Fontecha,Nagore Isabel Marín-Ramos,Carmen Ardanuy,Josefina Liñares,Pedro García,Ernesto García,José M. Sánchez-Puelles
Journal of Antimicrobial Chemotherapy. 2015; 70(9): 2608
[Pubmed]  [Google Scholar] [DOI]
51 Methylthiouracil, a new treatment option for sepsis
Soyoung Kwak,Sae-Kwang Ku,Hyejin Kang,Moon-Chang Baek,Jong-Sup Bae
Vascular Pharmacology. 2015;
[Pubmed]  [Google Scholar] [DOI]
52 Prediction of Drug Indications Based on Chemical Interactions and Chemical Similarities
Guohua Huang,Yin Lu,Changhong Lu,Mingyue Zheng,Yu-Dong Cai
BioMed Research International. 2015; 2015: 1
[Pubmed]  [Google Scholar] [DOI]
53 Discontinued anxiolytic drugs (2009 – 2014)
Roberto Mandrioli,Laura Mercolini
Expert Opinion on Investigational Drugs. 2015; 24(4): 557
[Pubmed]  [Google Scholar] [DOI]
54 Engaging patients for drug repurposing: mapping the patient engagement continuum
Minna Allarakhia
Clinical Investigation. 2015; 5(9): 733
[Pubmed]  [Google Scholar] [DOI]
55 Identifying Gastric Cancer Related Genes Using the Shortest Path Algorithm and Protein-Protein Interaction Network
Yang Jiang,Yang Shu,Ying Shi,Li-Peng Li,Fei Yuan,Hui Ren
BioMed Research International. 2014; 2014: 1
[Pubmed]  [Google Scholar] [DOI]
56 A Graphic Method for Identification of Novel Glioma Related Genes
Yu-Fei Gao,Yang Shu,Lei Yang,Yi-Chun He,Li-Peng Li,GuaHua Huang,Hai-Peng Li,Yang Jiang
BioMed Research International. 2014; 2014: 1
[Pubmed]  [Google Scholar] [DOI]
57 Repositioning of 2,4-Dichlorophenoxy acetic acid as a potential anti-inflammatory agent: In Silico and Pharmaceutical Formulation study
Mohammed A. Khedr,Tamer M. Shehata,Maged E. Mohamed
European Journal of Pharmaceutical Sciences. 2014; 65: 130
[Pubmed]  [Google Scholar] [DOI]
58 Repurposing drugs for the treatment and control of helminth infections
Gordana Panic,Urs Duthaler,Benjamin Speich,Jennifer Keiser
International Journal for Parasitology: Drugs and Drug Resistance. 2014; 4(3): 185
[Pubmed]  [Google Scholar] [DOI]
59 Challenges and opportunities of drug repositioning
Natalia Novac
Trends in Pharmacological Sciences. 2013; 34(5): 267
[Pubmed]  [Google Scholar] [DOI]
60 Open-source approaches for the repurposing of existing or failed candidate drugs: Learning from and applying the lessons across diseases
Allarakhia, M.
Drug Design, Development and Therapy. 2013; 7: 753-766
[Pubmed]  [Google Scholar]
61 Challenges and opportunities of drug repositioning
Novac, N.
Trends in Pharmacological Sciences. 2013; 34(5): 267-272
[Pubmed]  [Google Scholar]
62 Are GPCRs Still a Source of New Targets?
Stephen L. Garland
SLAS Discovery. 2013; 18(9): 947
[Pubmed]  [Google Scholar] [DOI]
63 Drug repositioning for orphan genetic diseases through Conserved Anticoexpressed Gene Clusters (CAGCs)
Ivan Molineris,Ugo Ala,Paolo Provero,Ferdinando Di Cunto
BMC Bioinformatics. 2013; 14(1): 288
[Pubmed]  [Google Scholar] [DOI]
64 Discontinued drugs in 2012: cardiovascular drugs
Hong-Ping Zhao,Hong-Min Jiang,Bing-Ren Xiang
Expert Opinion on Investigational Drugs. 2013; 22(11): 1437
[Pubmed]  [Google Scholar] [DOI]
65 Drug reformulations and repositioning in pharmaceutical industry and its impact on market access: reassessment of nomenclature
Murteira Susana,Ghezaiel Zied,Karray Slim,Lamure Michel
Journal of Market Access & Health Policy. 2013; 1(0)
[Pubmed]  [Google Scholar] [DOI]
66 Systematic identification of small molecule adjuvants
Darren R Flower
Expert Opinion on Drug Discovery. 2012; 7(9): 807
[Pubmed]  [Google Scholar] [DOI]
67 Orphan/rare drug discovery through drug repositioning
Muthyala, R.
Drug Discovery Today: Therapeutic Strategies. 2012; 8(3-4): 71-76
[Pubmed]  [Google Scholar]
68 Systematic identification of small molecule adjuvants
Flower, D.R.
Expert Opinion on Drug Discovery. 2012; 7(9): 807-817
[Pubmed]  [Google Scholar]
69 The role of academic institutions in the development of drugs for rare and neglected diseases
Coles, L.D. and Cloyd, J.C.
Clinical Pharmacology and Therapeutics. 2012; 92(2): 193-202
[Pubmed]  [Google Scholar]
70 Nonprofit drugs as the salvation of the worldæs healthcare systems: The case of Antabuse (disulfiram)
Cvek, B.
Drug Discovery Today. 2012; 17(9-10): 409-412
[Pubmed]  [Google Scholar]
71 Cancer cell senescence: A new frontier in drug development
Cairney, C.J., Bilsland, A.E., Evans, T.R.J., Roffey, J., Bennett, D.C., Narita, M., Torrance, C.J., Keith, W.N.
Drug Discovery Today. 2012; 17(5-6): 269-276
[Pubmed]  [Google Scholar]
72 Drug repositioning for personalized medicine
Li, Y.Y., Jones, S.J.M.
Genome Medicine. 2012; 4(3): art -27
[Pubmed]  [Google Scholar]
73 Identification of common biological pathways and drug targets across multiple respiratory viruses based on human host gene expression analysis
Smith, S.B., Dampier, W., Tozeren, A., Brown, J.R., Magid-Slav, M.
PLoS ONE. 2012; 7(3): art -33174
[Pubmed]  [Google Scholar]
74 Nonprofit drugs as the salvation of the worldæs healthcare systems: the case of Antabuse (disulfiram)
Boris Cvek
Drug Discovery Today. 2012; 17(9-10): 409
[Pubmed]  [Google Scholar] [DOI]
75 Cancer cell senescence: a new frontier in drug development
Claire J. Cairney,Alan E. Bilsland,T.R. Jeffry Evans,Jon Roffey,Dorothy C. Bennett,Masashi Narita,Christopher J. Torrance,W. Nicol Keith
Drug Discovery Today. 2012; 17(5-6): 269
[Pubmed]  [Google Scholar] [DOI]
76 The Role of Academic Institutions in the Development of Drugs for Rare and Neglected Diseases
L D Coles,J C Cloyd
Clinical Pharmacology & Therapeutics. 2012; 92(2): 193
[Pubmed]  [Google Scholar] [DOI]
77 Orphan/rare drug discovery through drug repositioning
Ramaiah Muthyala
Drug Discovery Today: Therapeutic Strategies. 2011; 8(3-4): 71
[Pubmed]  [Google Scholar] [DOI]

 

Online since 12th February '04
© 2004 - Journal of Postgraduate Medicine
Official Publication of the Staff Society of the Seth GS Medical College and KEM Hospital, Mumbai, India
Published by Wolters Kluwer - Medknow