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Drug repositioning: Re-investigating existing drugs for new therapeutic indications

Padhy B M, Gupta Y K

Year : 2011| Volume: 57| Issue : 2 | Page no: 153-160

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[Pubmed]  [Google Scholar] [DOI]
2 The Contribution of Clinical Pharmacologists in Precision Medicine: An Opportunity for Health Care Improvement
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3 Repurposing old molecules for new indications: Defining pillars of success from lessons in the past
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4 Rational drug repurposing for cancer by inclusion of the unbiased molecular dynamics simulation in the structure-based virtual screening approach: Challenges and breakthroughs
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30 Methylthiouracil, a new treatment option for sepsis
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[Pubmed]  [Google Scholar] [DOI]
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[Pubmed]  [Google Scholar] [DOI]
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37 Challenges and opportunities of drug repositioning
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[Pubmed]  [Google Scholar] [DOI]
38 Open-source approaches for the repurposing of existing or failed candidate drugs: Learning from and applying the lessons across diseases
Allarakhia, M.
Drug Design, Development and Therapy. 2013; 7: 753-766
[Pubmed]  [Google Scholar]
39 Challenges and opportunities of drug repositioning
Novac, N.
Trends in Pharmacological Sciences. 2013; 34(5): 267-272
[Pubmed]  [Google Scholar]
40 Drug reformulations and repositioning in pharmaceutical industry and its impact on market access: reassessment of nomenclature
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Journal of Market Access & Health Policy. 2013; 1(0)
[Pubmed]  [Google Scholar] [DOI]
41 Drug repositioning for orphan genetic diseases through Conserved Anticoexpressed Gene Clusters (CAGCs)
Ivan Molineris,Ugo Ala,Paolo Provero,Ferdinando Di Cunto
BMC Bioinformatics. 2013; 14(1): 288
[Pubmed]  [Google Scholar] [DOI]
42 Discontinued drugs in 2012: cardiovascular drugs
Hong-Ping Zhao,Hong-Min Jiang,Bing-Ren Xiang
Expert Opinion on Investigational Drugs. 2013; 22(11): 1437
[Pubmed]  [Google Scholar] [DOI]
43 Systematic identification of small molecule adjuvants
Darren R Flower
Expert Opinion on Drug Discovery. 2012; 7(9): 807
[Pubmed]  [Google Scholar] [DOI]
44 Orphan/rare drug discovery through drug repositioning
Muthyala, R.
Drug Discovery Today: Therapeutic Strategies. 2012; 8(3-4): 71-76
[Pubmed]  [Google Scholar]
45 Systematic identification of small molecule adjuvants
Flower, D.R.
Expert Opinion on Drug Discovery. 2012; 7(9): 807-817
[Pubmed]  [Google Scholar]
46 The role of academic institutions in the development of drugs for rare and neglected diseases
Coles, L.D. and Cloyd, J.C.
Clinical Pharmacology and Therapeutics. 2012; 92(2): 193-202
[Pubmed]  [Google Scholar]
47 Nonprofit drugs as the salvation of the worldæs healthcare systems: The case of Antabuse (disulfiram)
Cvek, B.
Drug Discovery Today. 2012; 17(9-10): 409-412
[Pubmed]  [Google Scholar]
48 Cancer cell senescence: A new frontier in drug development
Cairney, C.J., Bilsland, A.E., Evans, T.R.J., Roffey, J., Bennett, D.C., Narita, M., Torrance, C.J., Keith, W.N.
Drug Discovery Today. 2012; 17(5-6): 269-276
[Pubmed]  [Google Scholar]
49 Drug repositioning for personalized medicine
Li, Y.Y., Jones, S.J.M.
Genome Medicine. 2012; 4(3): art -27
[Pubmed]  [Google Scholar]
50 Identification of common biological pathways and drug targets across multiple respiratory viruses based on human host gene expression analysis
Smith, S.B., Dampier, W., Tozeren, A., Brown, J.R., Magid-Slav, M.
PLoS ONE. 2012; 7(3): art -33174
[Pubmed]  [Google Scholar]
51 Nonprofit drugs as the salvation of the worldæs healthcare systems: the case of Antabuse (disulfiram)
Boris Cvek
Drug Discovery Today. 2012; 17(9-10): 409
[Pubmed]  [Google Scholar] [DOI]
52 Cancer cell senescence: a new frontier in drug development
Claire J. Cairney,Alan E. Bilsland,T.R. Jeffry Evans,Jon Roffey,Dorothy C. Bennett,Masashi Narita,Christopher J. Torrance,W. Nicol Keith
Drug Discovery Today. 2012; 17(5-6): 269
[Pubmed]  [Google Scholar] [DOI]
53 The Role of Academic Institutions in the Development of Drugs for Rare and Neglected Diseases
L D Coles,J C Cloyd
Clinical Pharmacology & Therapeutics. 2012; 92(2): 193
[Pubmed]  [Google Scholar] [DOI]
54 Orphan/rare drug discovery through drug repositioning
Ramaiah Muthyala
Drug Discovery Today: Therapeutic Strategies. 2011; 8(3-4): 71
[Pubmed]  [Google Scholar] [DOI]


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