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Year : 2022  |  Volume : 68  |  Issue : 4  |  Page : 236-238

Unusual magnetic resonance imaging findings of cystic bone lesions in congenital generalized lipodystrophy

1 Tesla Diagnostic Imaging, Brasilia, Brazil
2 Base Hospital of the Federal District, Brasilia, Brazil
3 Unimed Sul Capixaba Hospital, Cachoeiro de Itapemirim, Brazil

Correspondence Address:
B B Machado
Unimed Sul Capixaba Hospital, Cachoeiro de Itapemirim
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/jpgm.jpgm_1031_21

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Cystic bone lesions are the hallmark of skeletal abnormalities in patients with congenital generalized lipodystrophy (CGL). However, their pathophysiology is still unclear and theories about their origin remain largely speculative. This article reports on a patient with CGL and cystic bone lesions, some of them with unusual magnetic resonance imaging (MRI) findings that include elevated signal intensity on T1-weighted images and fluid–fluid levels, the latter evolving to a more “classic” cystic appearance on follow-up. Even though similar findings were first described almost 30 years ago, little attention was given to them back then; furthermore, other than the present report, no other study has performed sequential exams to follow their evolution in serial MRI. The authors conduct a review of the literature, hypothesizing that these remarkable findings may reflect an intermediate stage in the process of cystification of the abnormal bone marrow, incapable to perform adipose conversion, lending factual support to the modern theories about this issue.


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Online since 12th February '04
2004 - Journal of Postgraduate Medicine
Official Publication of the Staff Society of the Seth GS Medical College and KEM Hospital, Mumbai, India
Published by Wolters Kluwer - Medknow