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| CASE REPORT |
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| Year : 2016 | Volume
: 62
| Issue : 1 | Page : 40-43 |
Persistent γδ T large granular lymphocytosis in a patient with refractory pure red cell aplasia, celiac disease, and chronic hepatitis B infection
S Sreedharanunni1, MUS Sachdeva1, G Prakash2, R Das1
1 Department of Hematology, Post Graduate Institute of Medical Education and Research, Chandigarh, Punjab and Haryana, India
2 Department of Internal Medicine, Post Graduate Institute of Medical Education and Research, Chandigarh, Punjab and Haryana, India
Correspondence Address:
R Das
Department of Hematology, Post Graduate Institute of Medical Education and Research, Chandigarh, Punjab and Haryana
India
 Source of Support: None, Conflict of Interest: None  | Check |
DOI: 10.4103/0022-3859.168739
The disorders of large granular lymphocytes include reactive proliferation as well as indolent or aggressive neoplasms of cytotoxic T cells, γδ T cells, and natural killer (NK) cells. They are associated with autoimmune and infectious disorders and have varied immunophenotypic features. We report a case, which highlights this complex association of autoimmune and infectious diseases with large granular lymphocytosis, the overlapping spectrum of large granular lymphocyte leukemias, and γδ T cell lymphomas as well as the difficulties in the diagnosis and management of these indolent T cell lymphomas in the usual clinical settings.
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