Journal of Postgraduate Medicine
 Open access journal indexed with Index Medicus & ISI's SCI  
Users online: 311  
Home | Subscribe | Feedback | Login 
About Latest Articles Back-Issues Articlesmenu-bullet Search Instructions Online Submission Subscribe Etcetera Contact
 ::  Similar in PUBMED
 ::  Search Pubmed for
 ::  Search in Google Scholar for
 ::  Article in PDF (1,078 KB)
 ::  Citation Manager
 ::  Access Statistics
 ::  Reader Comments
 ::  Email Alert *
 ::  Add to My List *
* Registration required (free) 

  IN THIS Article
 :: Acknowledgments
 ::  References
 ::  Article Figures

 Article Access Statistics
    PDF Downloaded12    
    Comments [Add]    
    Cited by others 5    

Recommend this journal


  Table of Contents     
Year : 2013  |  Volume : 59  |  Issue : 3  |  Page : 245-246

Acute onset myopia as a presenting feature of systemic lupus erythematosus

1 Department of Ophthalmology, Kasturba Medical College, Manipal, Karnataka, India
2 Department of Dermatology, Kasturba Medical College, Manipal, Karnataka, India

Date of Web Publication12-Sep-2013

Correspondence Address:
Y S Kamath
Department of Ophthalmology, Kasturba Medical College, Manipal, Karnataka
Login to access the Email id

Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0022-3859.118060

Rights and Permissions

How to cite this article:
Kamath Y S, Singh A, Bhat S S, Sripathi H. Acute onset myopia as a presenting feature of systemic lupus erythematosus. J Postgrad Med 2013;59:245-6

How to cite this URL:
Kamath Y S, Singh A, Bhat S S, Sripathi H. Acute onset myopia as a presenting feature of systemic lupus erythematosus. J Postgrad Med [serial online] 2013 [cited 2023 May 28];59:245-6. Available from:


Systemic lupus erythematosus (SLE) is a multisystem immunological disorder with myriad ocular features. [1] We report a rare presentation of blurred vision due to acute myopia, with only few such cases reported in the literature. A 19-year-old female presented with symptoms of bilateral lid edema and blurred vision since 3 days. She gave a history of skin rashes on her forearms and face with intermittent fever and joint pain in the last 6 months. She denied taking any oral medications for her condition. There was no history of prior ocular disease or trauma. On examination, the visual acuity in oculi uterque (OU) was 20/20; N6 with a correction of − 4.25 D sphere. Intraocular pressure in both her eyes was 22 mmHg. There was a maculopapular rash over the malar region of face with bilateral lid edema and conjunctival chemosis [Figure 1]. Anterior chamber was quiet but shallow on gonioscopy. Anterior chamber depth by immersion A-scan ultrasonography in oculus dexter (OD) was 2.53 mm; oculus sinister (OS) was 2.46 mm. Fundus examination was normal except for retinal folds in the macula in OU [Figure 2]. B scan ultrasonography showed features of annular ciliochoroidal effusion and a "T"-sign suggestive of posterior scleritis [Figure 3]. She was started on topical prednisolone drops q 4 th hourly and homatropine eye drops q 8 th hourly in OU. A Dermatology opinion of the papular lesions with photoaggravation pointed toward systemic lupus erythematous (SLE). Her blood pressure was normal. Her hemoglobin was 9.3 g/dl; Erythrocyte sedimentation rate was 92 mm/1 h. Anti-nuclear antibody (global) was strongly positive. Renal function was normal apart from mild proteinuria. Histopathological and immunofluorescence studies confirmed SLE. She was added on systemic steroids and hydroxychloroquine.
Figure 1: Bilateral lid edema with malar rash

Click here to view
Figure 2: Retinal striae

Click here to view
Figure 3: Ocular ultrasound bscan showing early T sign

Click here to view

On follow-up after 2 weeks, her unaided vision OU had improved to 20/20; N6, with an intraocular pressure of 9 mmHg and her lid edema had significantly decreased [Figure 4]. Anterior chamber had deepened with depth of OD: 3.77 mm; OS: 3.76 mm. B-scan showed a resolution of the anterior choroidal effusion and T sign.
Figure 4: At 1 month follow‑up: Resolved lid edema

Click here to view

In SLE, diminution of vision may be secondary to keratoconjunctivitis sicca, posterior scleritis with retinal involvement, lupus retinopathy and choroidopathy and optic neuritis. [1] The presentation of SLE with acute myopia has been rarely reported.

Acute onset of myopia results either due to changes in the curvature or refractive index of the lens or the anterior shift of the iris lens diaphragm.

The anterior displacement of the iris lens diaphragm is seen in ciliochoroidal effusion, ocular blunt trauma and with the use of miotics like pilocarpine. Ciliochoroidal effusion has been attributed to posterior scleritis [2] and use of drugs including topiramate and hydrochlorothiazide. [3],[4]

In our patient, a negative drug history, refractive evaluation, supported by the shallow anterior chamber suggest acute onset myopia due to anterior displacement of the iris lens diaphragm, in turn due to posterior scleritis and ciliochoroidal effusion secondary to SLE.

Hung et al. have reported a patient with SLE in whom they have documented the forward rotation of the ciliary body as the cause for transient myopia, using ultrasound biomicroscopy. [5] However in our patient, due to technical reasons the same could not be done at presentation.

This case highlights an unusual presentation of a multisystem disorder and the role of ophthalmological evaluation in SLE.

 :: Acknowledgments Top

We would like to thank the Photography team of Department of Ophthalmology and the Heads of Departments of Ophthalmology and Dermatology.

 :: References Top

1.Palejwala NV, Walia HS, Yeh S. Ocular manifestations of systemic lupus erythematosus: A review of the literature. Autoimmune Dis 2012;2012:290898.  Back to cited text no. 1
2.Ikeda N, Ikeda T, Nomura C, Mimura O. Ciliochoroidal effusion syndrome associated with posterior scleritis. Jpn J Ophthalmol 2007;51:49-52.  Back to cited text no. 2
3.Bhattacharyya KB, Basu S. Acute myopia induced by topiramate: Report of a case and review of the literature. Neurol India 2005;53:108-9.  Back to cited text no. 3
[PUBMED]  Medknow Journal  
4.Roh YR, Woo SJ, Park KH. Acute-onset bilateral myopia and ciliochoroidal effusion induced by hydrochlorothiazide. Korean J Ophthalmol 2011;25:214-7.  Back to cited text no. 4
5.Hung KC, Hsueh PY, Wang NK, Su WW, Tan HY. Transient myopic shifting in systemic lupus erythematosus. Lupus 2011;20:334-5.  Back to cited text no. 5


  [Figure 1], [Figure 2], [Figure 3], [Figure 4]

This article has been cited by
1 Lupus-Induced Myopic Shift
Sara Safari, Thomas A Weppelmann
Cureus. 2022;
[Pubmed] | [DOI]
2 Visually induced changes in cytokine production in the chick choroid
Jody A Summers, Elizabeth Martinez
eLife. 2021; 10
[Pubmed] | [DOI]
3 Inflammatory cytokines in highly myopic eyes
Jianshu Yuan, Shanjun Wu, Yuewen Wang, Suqi Pan, Pengyun Wang, Lingyun Cheng
Scientific Reports. 2019; 9(1)
[Pubmed] | [DOI]
4 Role of Chronic Inflammation in Myopia Progression: Clinical Evidence and Experimental Validation
Hui-Ju Lin, Chang-Ching Wei, Ching-Yao Chang, Ter-Hsin Chen, Yu-An Hsu, Yi-Ching Hsieh, Hsuan-Ju Chen, Lei Wan
eBioMedicine. 2016; 10: 269
[Pubmed] | [DOI]
5 Acute onset myopia A rare presentation of systemic lupus erythematosus
Parth Patel,V.S. Gurunadh,S. Shankar,M.A. Khan
Medical Journal Armed Forces India. 2015; 71: S560
[Pubmed] | [DOI]


Print this article  Email this article
Online since 12th February '04
2004 - Journal of Postgraduate Medicine
Official Publication of the Staff Society of the Seth GS Medical College and KEM Hospital, Mumbai, India
Published by Wolters Kluwer - Medknow