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Year : 2013  |  Volume : 59  |  Issue : 2  |  Page : 131-134

Cerebral demyelination in children with collagenous colitis

1 Department of Pediatrics, Louisiana State University Health Sciences Center, Shreveport, Louisiana, USA
2 Department of Pediatric Gastroenterology, Oklahoma University Health Sciences Center, Oklahoma City, Oklahoma, USA
3 Delta Pathology, Shreveport, Louisiana, USA
4 WK Pediatric Gastroenterology and Research, Willis-Knighton Hospital, Shreveport, Louisiana, USA

Correspondence Address:
S Z Hussain
WK Pediatric Gastroenterology and Research, Willis-Knighton Hospital, Shreveport, Louisiana
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0022-3859.113848

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Collagenous colitis (CC) is a form of microscopic colitis characterized by the presence of inflammatory infiltrate and subepithelial deposition of collagen in the colon and it is a rare condition with a predominant prevalence in the adult population. Only few cases have been reported in children. We report two children with the CC with concomitant neurological manifestations. Both cases demonstrated variable neurological symptoms clinically and significant cerebral demyelination. In both patients, the gastrointestinal manifestations drastically improved with a short course of prednisolone. However, the neurological symptoms were persistent and progressive. To the best of our knowledge, similar association has not been reported in children.


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Online since 12th February '04
2004 - Journal of Postgraduate Medicine
Official Publication of the Staff Society of the Seth GS Medical College and KEM Hospital, Mumbai, India
Published by Wolters Kluwer - Medknow