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| CASE REPORT |
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| Year : 2008 | Volume
: 54
| Issue : 2 | Page : 135-137 |
Hypereosinophilic syndrome with isolated Loeffler's endocarditis: Complete resolution with corticosteroids
T Sen, CK Ponde, ZF Udwadia
Department of Pulmonology, PD Hinduja National Hospital and Medical Research Centre, Mahim, Mumbai - 400016, India
Correspondence Address:
Z F Udwadia
Department of Pulmonology, PD Hinduja National Hospital and Medical Research Centre, Mahim, Mumbai - 400016
India
 Source of Support: None, Conflict of Interest: None  | Check |
DOI: 10.4103/0022-3859.40780
Hypereosinophilic syndrome (HES) is classically defined as prolonged, unexplained peripheral eosinophilia in a patient presenting with evidence of end-organ damage. The heart is involved in two forms; endomyocardial fibrosis (Davies disease) and eosinophilic endocarditis (Loffler's endocarditis). It was first reported in 1968 by Hard and Anderson. Chusid and co-workers formulated a definition with strict criteria for the diagnosis of HES as 1) peripheral blood eosinophilia more than 1500 cells/cu mm for at least six months duration 2)signs, symptoms of end-organ (heart, lungs, gastrointestinal tract, skin, bone-marrow, brain) involvement with eosinophil tissue infiltration/injury 3) exclusion of known secondary causes of eosinophilia. We report a case of hypereosinophilic syndrome with Loffler's endocarditis, in the absence of endomyocardial fibrosis. The patient presented with a eosinophilic vegetation over the posterior leaflet of the mitral valve. There was complete resolution of the vegetation after two months of corticosteroid therapy.
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