Journal of Postgraduate Medicine
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Year : 2008  |  Volume : 54  |  Issue : 1  |  Page : 35-36

Citrobacter freundii infection in glutaric aciduria type 1: Adding insult to injury

Department of Microbiology, Kasturba Medical College, Manipal, Karnataka, India

Correspondence Address:
C Mukhopadhyay
Department of Microbiology, Kasturba Medical College, Manipal, Karnataka
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0022-3859.39189

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Glutaric aciduria type 1 (GA1) is an inborn error of organic acid metabolism, where the brain is the principal organ affected with exposure to toxic metabolic product, 3-hydroxyglutaric acid (3-OHGA). A 2-year-old boy with GA1 and delayed developmental milestones had an acute neurological crisis leading to massive brain abscess with Citrobacter freundi infection, a rare cause of neonatal meningitis and often associated with brain abscess. Both 3-OHGA and C. freundii can damage the blood-brain barrier and can cause significant trauma which demands immediate and appropriate management. Encephalopathic manifestations of GA1 may consequently increase the risk of meningeal infection and it has not been previously documented.


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Online since 12th February '04
2004 - Journal of Postgraduate Medicine
Official Publication of the Staff Society of the Seth GS Medical College and KEM Hospital, Mumbai, India
Published by Wolters Kluwer - Medknow