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Year : 2006  |  Volume : 52  |  Issue : 1  |  Page : 5-10

Cardiovascular involvement in systemic lupus erythematosus: An autopsy study of 27 patients in India

Department of Pathology, Seth G. S. Medical College and K.E.M. Hospital, Parel, Mumbai-400012, India

Correspondence Address:
Smita Divate
Department of Pathology, Seth G. S. Medical College and K.E.M. Hospital, Parel, Mumbai-400012
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Source of Support: None, Conflict of Interest: None

PMID: 16534157

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Background: Although cardiovascular disease (CVD) is recognized as a leading cause of death in patients with systemic lupus erythematosus (SLE) in western countries, there is hardly any data regarding Indian subjects with SLE. Aims: To determine the incidence of cardiac abnormalities and vascular lesions at autopsy and to assess their contribution to the mortality in patients with SLE Settings and Design: Retrospective retrieval of reports of autopsies performed on 35 patients with SLE over a 11 year period and analysis of 27 cases with cardiac and/or vascular lesions. Materials and Methods: Gross and microscopic features in 27 autopsies were analyzed with special attention to the heart and the vasculature of all organs. Findings were correlated with clinical features and ante-mortem investigations. Their contribution towards mortality was assessed. Results: Valvar lesions were the commonest cardiac lesions noted with non-bacterial thrombotic endocarditis in nine (33.33%), valvar thickening in two (7.41%), Libman-Sacks endocarditis and infective endocarditis in one (3.70%) each. Myocarditis and myocardial scarring were seen in 10 (37.03%) and seven (25.92%) cases, respectively. Fibrinous pericarditis was noted in seven (25.92%). Thromboses/ embolism, vasculitis and severe coronary atherosclerosis were seen in nine (33.33%), five (18.52%) and one (3.70%) subjects, respectively. Renal disease [13, 48.14%] and cardiovascular manifestations [8, 29.62%] were the leading causes of death in our patient population. Conclusion: CVD contributes significantly to the mortality in patients with SLE in India. It is second only to renal disease in this regard


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Online since 12th February '04
2004 - Journal of Postgraduate Medicine
Official Publication of the Staff Society of the Seth GS Medical College and KEM Hospital, Mumbai, India
Published by Wolters Kluwer - Medknow