Journal of Postgraduate Medicine
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Year : 1996  |  Volume : 42  |  Issue : 1  |  Page : 12-4

The influence of surgical stress on the psychoneuro-endocrine-immune axis.

Department of Pharmacology, GS Medical College & KEM Hospital, Parel, Mumbai.

Correspondence Address:
S A Dahanukar
Department of Pharmacology, GS Medical College & KEM Hospital, Parel, Mumbai.

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Source of Support: None, Conflict of Interest: None

PMID: 0009715290

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Stress is known to depress the immune system severely. This study was done to evaluate whether surgical stress influenced polymorphonuclear (PMN) and monocyte functions in association with serum cortisol and the anxiety score as measured on the HARS Rating Scale. We found that surgery (irrespective of whether it was major or minor) significantly depressed PMN and monocyte functions and increased serum cortisol levels. PMN phagocytosis correlated significantly (p < 0.05) with the rise in serum cortisol. In spite of these changes, postoperative clinical recovery was uneventful. No major alterations in the HARS scores were noted pre and post operatively. This study demonstrates that surgical stress depresses the immune system with a concomitant rise in cortisol.


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Online since 12th February '04
2004 - Journal of Postgraduate Medicine
Official Publication of the Staff Society of the Seth GS Medical College and KEM Hospital, Mumbai, India
Published by Wolters Kluwer - Medknow