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| PAPERS |
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| Year : 1995 | Volume
: 41
| Issue : 3 | Page : 64-5 |
Roxatidine in duodenal ulcer.
CM Habibullah, MA Habeeb, SP Singh
Dept of Gastroenterology, Osmania Medical College, Osmania General Hospital, Hyderabad.
Correspondence Address:
C M Habibullah
Dept of Gastroenterology, Osmania Medical College, Osmania General Hospital, Hyderabad.
 Source of Support: None, Conflict of Interest: None  | Check |
PMID: 0010707717 
Roxatidine acetate is a new H2-receptor antagonist. A randomized double-blind clinical trial in fifty-three patients with endoscopically proven duodenal ulcers > 5 mm in diameter was undertaken to compare safety and efficacy of roxatidine with that of ranitidine. Twenty-six patients received roxatidine (75 mg bid) while 27 patients received ranitidine (150 mg bid) for 4 weeks. One patient in each group did not come for follow up. Roxatidine and ranitidine had comparable ulcer healing rates (22/25 vs 22/26); roxatidine, however, resulted in greater reduction in the number and severity of night time pain episodes (p < 0.05). No adverse event was reported during 4 weeks of treatment with roxatidine. Thus roxatidine achieves the primary therapeutic goal of relief of pain better than ranitidine.
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