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Year : 1992  |  Volume : 38  |  Issue : 3  |  Page : 124-6

Effect of ipratropium bromide in bronchial asthma.

Dept of Respiratory Medicine, KEM Hospital, Parel, Bombay, Maharashtra.

Correspondence Address:
V Taskar
Dept of Respiratory Medicine, KEM Hospital, Parel, Bombay, Maharashtra.

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Source of Support: None, Conflict of Interest: None

PMID: 0001303412

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The effect of inhalation of ipratropium bromide was evaluated in 20 patients with bronchial asthma. It was observed that there was no significant improvement in the forced vital capacity and the forced expired volume in one second, while there was significant improvement in the peak expiratory flow rate (PEFR) measured at 9 pm, after inhalation of 2 puffs of ipratropium bromide aerosol (0.02mg/puff) three to four times a day for 2 weeks. Since PEFR is a measure of large airway function and cholinergic mechanisms are primarily involved for airflow obstruction at large airways, improvement in PEFR by ipratropium bromide highlights its role as a useful bronchodilator in patients in whom vagal reflexes are responsible for the provocation of bronchoconstriction.


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Online since 12th February '04
2004 - Journal of Postgraduate Medicine
Official Publication of the Staff Society of the Seth GS Medical College and KEM Hospital, Mumbai, India
Published by Wolters Kluwer - Medknow