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| Year : 1990 | Volume
: 36
| Issue : 1 | Page : 16-9 |
Histiocytosis-X: role of histology and S-100 protein in grading the severity of disease.
SY Sane, KH Nainaney
Department of Pathology, Seth G. S. Medical College, Parel, Bombay, Maharashtra.
Correspondence Address:
S Y Sane
Department of Pathology, Seth G. S. Medical College, Parel, Bombay, Maharashtra.
 Source of Support: None, Conflict of Interest: None  | Check |
PMID: 0002097349 
Histiocytosis-X encompasses a wide clinical spectrum from a benign localised lesion to acute generalised disease with malignant behaviour. We have reviewed material from our 18 retrospective cases comparing histological features with clinical data. Degree of positivity for S-100 protein was studied by immunoperoxidase method. Our results indicate that diagnosis of histiocytosis-X necessitates histological confirmation but grading of histological criteria and S-100 positivity do not allow prediction of severity and extent of the disease.
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