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|Year : 1980 | Volume
| Issue : 4 | Page : 250-2
Glyceryl phosphoryl choline levels in cases of epididymitis.
Pardiwalla BB, Kulkarni PP, Pardanani DS
|How to cite this article:|
Pardiwalla B B, Kulkarni P P, Pardanani D S. Glyceryl phosphoryl choline levels in cases of epididymitis. J Postgrad Med 1980;26:250
The organic fraction of human seminal plasma contains glycerylphosphorylcholine (GPC). High concentrations of this substance are also found in the epididymis of several mammalian species ,, 
Glycerylphosphorylcholine is synthesised by the epithelial cells of the epididymis, apparantly under androgenic control.
In semen, GPC is present in high concentrations (upto 1%), in the ram, bull, goat, stallion and the rabbit. Comparatively low concentrations are found in the human semen.
These findings suggested that the epididymis could be a major source of GPC, and that the seminal levels of these substances might be useful indicators of the epididymal function.
Glycerylphosphorylcholine was estimated by the method of White.
The mean values of GPC in ug/ml. of seminal plasma and Standard Deviation (SD) values in all the three groups in this study are tabulated below:
The data was analysed using the student `T' test. The `T' value was calculated for vasectomised and for epididymitis patients, by comparison with normal controls.
The `P' value was also found out using the `T' table. Significantly low values of GPC were found in vasectomised and in patients with epididymitis.
A major part of GPC found in the semen is produced in the epididymis,,  and the concentration of this substance in the epididymal fluid is an important indicator of the epididymal function.
Small amounts of GPC are also produced in the accessory sex organs. This was shown in a study in which GP'C levels in the semen of patients with absence of vas deferens was only about 10% of those found in the normospermic men. 
Frenkel et al4 have shown that levels of GPC are significantly low in vasectomised patients; this was also confirmed in our studies. Pardanani et al have shown that the epididymis undergoes some gross changes after vasectomy which may be responsible for poor pregnancy rates after successful vas re-anastomosis.
However, Naik et al have observed that the decrease in the GPC levels in the seminal plasma after vasectomy were due to the mechanical blockage of the epididymal secretions. This was supported by their observations that within a month of successful vas re-anastomosis, the levels of GPC in semen returned to normal.
In our study, it was shown that in diseased conditions, the normal anatomy and physiology of the epididymis was disturbed, resulting in low levels of GPC in the semen.
Significantly low values of GPC in the semen were obtained in vasectomised patients and in cases with epididymitis. In this study, we have made no attempt to correlate the seminal levels of GPC to the severity of epididymal disease. The present study has shown that there is both a structural and functional change in the epididymis, with a resultant low levels of GPC in cases with epididymitis.
We owe our sincere thanks to Dr. V. K. Naik, Ph.D., for his help in this work. We also thank Dr. A. R. Sheth, Ph.D., for giving us permission to work in his department. Lastly we thank Dr. C. K. Deshpande, Dean, K.E.M.H., for giving us permission to publish this work.
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