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| ARTICLE |
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| Year : 1979 | Volume
: 25
| Issue : 3 | Page : 147-153 |
An experimental investigation to correlate changes in plasma fibrinolytic activity with isoprenaline induced myocardial damage
KK Saxena, B Gupta, VK Kulshrestha, DN Prasad
Department of Pharmacology, L.L.R.M, Medical College, Meerut-250102, India
Correspondence Address:
K K Saxena
Department of Pharmacology, L.L.R.M, Medical College, Meerut-250102
India
 Source of Support: None, Conflict of Interest: None  | Check |
PMID: 529166 
Administration of different doses of isoprenaline in albino rats produced varying grades of myocardial necrosis with concomitant changes in euglobulin clot lysis time which is a measure of plasma fibrinolytic activity (PFA). A positive and strong correlation was observed between changes in PFA and severity of myocardial necrosis. Experiments in young rats and propranolol pre-treated animals rule out the possibility of isoprenaline being responsible in bringing about changes in PFA. The measurement of PFA appears to be of prognostic significance in myocardial infarction as discussed.
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