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 ::  Introduction
 ::  Case report
 ::  Discussion
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Year : 1977  |  Volume : 23  |  Issue : 3  |  Page : 127-129

Pulmonary edema following lumbar puncture

Department of Tuberculosis and Chest Diseases, L.L.R.M. Medical College, Meerut, 250 102., India

Correspondence Address:
D K Gupta
Department of Tuberculosis and Chest Diseases, L.L.R.M. Medical College, Meerut, 250 102.
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Source of Support: None, Conflict of Interest: None

PMID: 614428

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 :: Abstract 

In a boy of 17 years with disseminated tuberculosis, sudden onset of pulmonary edema following lumbar puncture is described. Possible pat ho-mechanisms have been discussed. The link bet­ween the lumbar puncture and the development of pulmonary edema is not casual.

How to cite this article:
Gupta D K. Pulmonary edema following lumbar puncture. J Postgrad Med 1977;23:127-9

How to cite this URL:
Gupta D K. Pulmonary edema following lumbar puncture. J Postgrad Med [serial online] 1977 [cited 2023 Mar 23];23:127-9. Available from:

 :: Introduction Top

Pulmonary edema results when there is an abnormal accumulation of liquid and solute in the extravascular tissues and alveolar spaces of the lung. It may be due to loss of integrity of alveolo­capillary barrier or increase in the capil­lary pressure or decrease in the osmotic pressure leading to an excessive pressure gradient across the alveolo-capillary membrane. Altered premeability of the capillaries or of alveolar epithelium may complicate viral or bacterial infections, inhalation of toxins, ureamia, immuno­logical reactions and defects of coagula­tion. Increased pulmonary capillary pressure occurs in cardiac disorders such as left ventricular failure, mitral stenosis or myocardial infarction but may also be found in non-cardiac conditions like veno-occlusive disease, pulmonary ven­ous fibrosis, and mediastinal inflamma­tions. Further causes of pulmonary edema include hypoalbuminaemia, lymphatic insufficiency, narcotic over­dose, pulmonary embolism, parenchymal lung diseases, cardioversion, cardiopul­monary bypass surgery, high altitude and intravenous fluid therapy because of their effects on the compartments of the lung. Sudden development of pulmo­nary edema following pleural aspira­tion [10],[11],[12] and scorpion sting [6] have also been described.

However, failure to trace in the litera­ture any mention of development of acute pulmonary edema following lum­bar puncture has prompted us to report this case.

 :: Case report Top

A 17 years muslim boy was hospitalized on 12.2.1977 with disseminated tuberculosis of 2 months duration. The illness started with even­ing rise of temperature, cough with scanty whit­ish expectoration, night sweats and gradually diminishing appetite. For the last fortnight, fever was continuous. He was having occasional headaches, nausea and vomiting and had grown weaker. At the time of hospitalization he was drowsy, lethargic and with altered conscious­ness. He also complained of diffuse dull ache in the abdomen but denied any history of alter­nating diarrhoea and constipation. Previously, he used to get epileptic fits off and on, the last attack being about 3 months prior to admission. No history of injury or diabetes mellitus could be elicited. He was non-vegetarian and used to smoke about 20-30 bidis a day for the last 6 years.

He was ill looking with a pulse rate of 108/ minute, respiratory rate of 22/minute and tem­perature 38.8° C. Blood pressure was 98/82 mm Hg. He was anaemic. A few minute discrete glands were palpable in the cervical region.

On examination of the chest, a few fine cre­pitations in the right suprascapular area were found. Examination of the abdomen revealed a soft and tender liver palpable 4.5 cm below right subcostal margin. Diffuse tenderness of the abdomen was present on deep pressure but there was no palpable mass. Neck rigidity and Kernig's sign were positive without any other neurologic deficit. Presence of choroid tubercle could not be demonstrated.

Repeated examination of sputum was found negative for A.F.B. by direct microscopy. Tuber­culin test with 1 TU PPD RT 23 Tween 80 gave a sensitivity of 6 mm (negative). Posteroante­rior roentgenogram chest (12.2.77) showed miliary shadows throughout both the lung fields. Diagnostic lumbar puncture was done with the following observations: intracranial tension was raised (60 drops/minute), cerebrospinal fluid (CSF) was clear and formed cob-web, protien­100 mg%, sugar-42 mg%, chloride-550 mg% and cells-24/mm 3 mainly lymphocytes. Other investigations are shown in [Table 1].

The patient was put on a drug regimen con­sisting of Inj. Streptomycin sulphate 1 gm I.M. every 12 hours plus Isoniazid 600 mg once a day plus Ethambutol 800 mg once a day along with parenteral corticosteroid every 8 hourly, intravenous mannitol, anti-emetics and vitamin B.. During 11 days of hospitalization 4 bottles of mannitol were administered intermittently and 5 lumbar punctures were performed with a total withdrawal of 24.5 ml CSF. Dexamethasone 4 nig in 2 ml aquous solution was injected intra­thecally after 3rd, 4th and 5th procedures. There was some clinical improvement initially but by and large his general condition remained un­changed. CSF protein was continuously rising. On 22.2.77, within an hour of lumbar puncture his general condition suddenly worsened. Pulse rate went upto 136/minute, respiration rate 40/minute and B.P. 80 mm Hg (systolic). He was cyanosed. Both the lung fields were full of bubbling rales which were audible even with nacked ears. Some thin, frothy sputum was dribbling out of his mouth. Measures for pulmonary edema including intratracheal suction of the secretions were instituted immediately, but after a battle of about 5 hours the patient died without any decrease in pulmonary edema. His rela­tives refused postmortem examination.

 :: Discussion Top

Pulmonary edema following head in­juries, cerebral haemorrhage and certain other neurological conditions in which in­tracranial pressure is increased, have been reported. [3],[5],[9] Epileptic seizures [1],[7] ­and generalised convulsions [8] may also lead to pulmonary edema. It has been demonstrated that following acute rise in intracranial pressure, significant hemodynamic alterations take place namely rise of systemic, pulmonary arterial and left atrial pressures. [2],[4]

In the present case, pulmonary edema developed within an hour of withdrawal of 8 ml CSF (10 ml withdrawal minus 2 ml intrathecal injection of dexametha­sone). During his hospital stay of 11 days, only 4 bottles of I.V. mannitol were administered which could not have re­sulted in overloading of circulation Systemic blood pressures never indicated evidence of hypertension. It is possible that withdrawal of CSF had re­sulted in `Coning' with cardio-respira­tory distress, further acute increase in intracranial pressure and ultimately pulmonary edema. Another possibility is that intracranial hypotension resulting from withdrawal of CSF had brought up hemodynamic alterations in pulmonary circulation through some neurogenic mechanism and sympathetic hyperexcitation. This ultimately had resulted in extravasation of blood elements into the alveoli. However, pathogenesis of pulmonary edema in different conditions appear very complex and no single factor could be held responsible for its sudden appearance.

 :: References Top

1.Bonbrest, H. C.: `Pulmonary edema following an epileptic seizure.' Amer. Rev. Resp. Dis., 91: 97-100, 1965.  Back to cited text no. 1    
2.Brashear, R. E. and Pamintuan, H. L.: 'Increased pulmonary diffusing capacity and elevated cerebrospinal fluid pressure.' J. Appl. Physiol., 30: 844-846, 1971.  Back to cited text no. 2    
3.Ducker, T. B.: `Increased intracranial pressure and pulmonary edema-Part I. Clinical study of 11 patients.' J. Neuro­surg., 28: 112-117, 1968.   Back to cited text no. 3    
4.Ducker, T. B. and Simons, R. L.: 'In­creased intracranial pressure and pulmo­nary edema-Part II. Hernodynarnic response of dogs and monkeys to increas­ed intracranial pressure.' J. Neurosurg., 28: 118-123, 1968.  Back to cited text no. 4    
5.Ducker, T. B., Simons, R. L. and Martin, A. Jr.: `Pulmonary edema as a complica­tion of intracranial disease.' Amer. J. Child Dis., 118: 638-641, 1969.  Back to cited text no. 5    
6.Gadoth, N.: `Scorpion sting and pulmo­nary edema.' A letter to the Editor. New Engl. J. Med., 289: 1254, 1973.  Back to cited text no. 6    
7.Huff, R. W. and Fred, R. L.: 'Postictal pulmonary edema.' Arch. Intern. Med., 117: 824-828, 1966.  Back to cited text no. 7    
8.Malik, S. K., Zolinsky, H. and Graham, D. Y.: `Pulmonary edema following gene­ralised convulsions (Postictal).' Jr. Asso. Phys. Ind. 21: 795-797, 1973.  Back to cited text no. 8    
9.Richards, P.: 'Pulmonary edema and intra­cranial lesions.' Brit. Med. J., 2: 83-86, 1963.  Back to cited text no. 9    
10.Saini, G. S.: `Unilateral pulmonary edema after drainage of spontaneous pneumotho­rax.' Brit. Med. J., 1: 615, 1974.  Back to cited text no. 10    
11.Steckel, R. J.: 'Unilateral pulmonary edema after pneumothorax.' New Engl. J. Med., 289: 621-622, 1973.  Back to cited text no. 11    
12.Ziskind, M.: `Unilateral pulmonary edema after pleural aspiration.' Lancet, 2: 366, 1970.  Back to cited text no. 12    


  [Table 1]


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