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| ARTICLE |
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| Year : 1977 | Volume
: 23
| Issue : 2 | Page : 73-76 |
Propane 1, 2-diol (propylene glycol): A new phlogistic agent in mice
Kala M Mogre1, SR Amladi1, PD Soman2, UK Sheth1
1 Department of Pharmacology, Seth G. S. Medical College, Parel, Bombay-400012, India
2 Radiopharmaceutical Division, Bhabha Atomic Research Centre, Bombay, India
Correspondence Address:
Kala M Mogre
Department of Pharmacology, Seth G. S. Medical College, Parel, Bombay-400012
India
 Source of Support: None, Conflict of Interest: None  | Check |
PMID: 614417 
Propane 1, 2-diol (CH 3 -CHOH. CH 2 OH mol. wt. 76.10), a low molecular weight substance produced well defined inflammatory edema in hind paw of mice. Edema was concentration dependent. Submaximal edema occurred with 50% propylene glycol. Hydrocortisone, aspirin, phenylbutazone, indomethacin given orally were significantly effective against this edema. There was also an increase in the capillary permeability with propylene glycol edema. Lack of effect of chlorpheniramine, cyproheptadine and polymyxin B on edema suggest that histamine and serotonin are not involved in the mechnism of propylene glycol edema.
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