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Year : 1977  |  Volume : 23  |  Issue : 2  |  Page : 73-76

Propane 1, 2-diol (propylene glycol): A new phlogistic agent in mice

1 Department of Pharmacology, Seth G. S. Medical College, Parel, Bombay-400012, India
2 Radiopharmaceutical Division, Bhabha Atomic Research Centre, Bombay, India

Correspondence Address:
Kala M Mogre
Department of Pharmacology, Seth G. S. Medical College, Parel, Bombay-400012
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Source of Support: None, Conflict of Interest: None

PMID: 614417

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Propane 1, 2-diol (CH 3 -CHOH. CH 2 OH mol. wt. 76.10), a low molecular weight substance produced well defined inflammatory edema in hind paw of mice. Edema was concentration dependent. Submaximal edema occurred with 50% propylene glycol. Hydro­cortisone, aspirin, phenylbutazone, indomethacin given orally were significantly effective against this edema. There was also an increase in the capillary permeability with propylene glycol edema. Lack of effect of chlorpheniramine, cyproheptadine and polymyxin B on edema suggest that histamine and serotonin are not involved in the mechnism of propylene glycol edema.

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Online since 12th February '04
© 2004 - Journal of Postgraduate Medicine
Official Publication of the Staff Society of the Seth GS Medical College and KEM Hospital, Mumbai, India
Published by Wolters Kluwer - Medknow