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Year : 1976  |  Volume : 22  |  Issue : 4  |  Page : 161-170

Studies on the mechanism of hypotensive action of a disubstituted piperazine derivative - (Part II)

Department of Pharmacology, Seth G. S. Medical College, Parel, Bombay-400012, India

Correspondence Address:
N K Dadkar
Hoechst Research Centre, Mulund, Bombay-400080.
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Source of Support: None, Conflict of Interest: None

PMID: 1032831

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The mechanism of hypotensive action of R-1230, a new disub­stituted piperazine derivative was studied in anaesthetised normo­tensive cats. Rapid intravenous injection of R-1230 produced an immediate transient fall in blood pressure attributable to a direct peripheral vasodilator action as concluded from cat's hindquarters' perfusion experiment. The prolonged secondary hypotensive re­sponse appeared to be of complex nature. Inhibition of centrally mediated pressor reflexes on intracerebroventricular administra­tion, accompanied by peripheral adrenergic blockade, points to the dual mechanism of drug induced hypotension. Results in decere­brate and spinal preparations indicated the lower brainstem region lo be the principal site of central hypotensive action.

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Online since 12th February '04
© 2004 - Journal of Postgraduate Medicine
Official Publication of the Staff Society of the Seth GS Medical College and KEM Hospital, Mumbai, India
Published by Wolters Kluwer - Medknow