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Erythrophagocytosis by blasts in a case of de novo acute monoblastic leukemia with rare but characteristic t(8;16)


1 Department of Hematopathology and Genetics, AMPATH, Nallagandla, Serilingampally Hyderabad, Telangana, India
2 Department of Medical Oncology, Manipal Super Specialty Hospital, Vijaywada, Andhra Pradesh, India

Correspondence Address:
A Gupta,
Department of Hematopathology and Genetics, AMPATH, Nallagandla, Serilingampally, Hyderabad, Telangana
India
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Source of Support: None, Conflict of Interest: None

Erythrophagocytosis by leukemic blasts is a rare phenomenon. We report a case of a female diagnosed with acute monoblastic leukemia with leukemic blasts that were CD34 and CD117 negative, showing erythrophagocytosis, vacoulations, and a rare t(8;16) on bone marrow karyotype which is associated with a poor prognosis despite intensive chemotherapy. Meticulous bone marrow examination in such a scenario may point towards the presence of t(8;16) and help clinicians take a well-informed clinical decision.


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    -  Gupta A
    -  Reddy G K
    -  Goyal M
    -  Kasaragadda M R
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Online since 12th February '04
2004 - Journal of Postgraduate Medicine
Official Publication of the Staff Society of the Seth GS Medical College and KEM Hospital, Mumbai, India
Published by Wolters Kluwer - Medknow