Journal of Postgraduate Medicine
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Year : 2007  |  Volume : 53  |  Issue : 2  |  Page : 121-127

Adult mesenchymal stem cells: Differentiation potential and therapeutic applications


Wolfson Centre for Stem Cells, Tissue Engineering and Modelling ('STEM'), University of Nottingham, Nottingham NG7 2UH, United Kingdom

Correspondence Address:
V Sottile
Wolfson Centre for Stem Cells, Tissue Engineering and Modelling ('STEM'), University of Nottingham, Nottingham NG7 2UH
United Kingdom
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0022-3859.32215

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Adult mesenchymal stem cells (MSCs) are a population of multipotent cells found primarily in the bone marrow. They have long been known to be capable of osteogenic, adipogenic and chondrogenic differentiation and are currently the subject of a number of trials to assess their potential use in the clinic. Recently, the plasticity of these cells has come under close scrutiny as it has been suggested that they may have a differentiation potential beyond the mesenchymal lineage. Myogenic and in particular cardiomyogenic potential has been shown in vitro . MSCs have also been shown to have the ability to form neural cells both in vitro and in vivo , although the molecular mechanisms underlying these apparent transdifferentiation events are yet to be elucidated. We describe here the cellular characteristics and differentiation potential of MSCs, which represent a promising stem cell population for future applications in regenerative medicine.






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Online since 12th February '04
2004 - Journal of Postgraduate Medicine
Official Publication of the Staff Society of the Seth GS Medical College and KEM Hospital, Mumbai, India
Published by Wolters Kluwer - Medknow